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KMID : 0616620010070020313
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Journal of Soonchunhyang Medical College
2001 Volume.7 No. 2 p.313 ~ p.319
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Immunohistochemical Expression of bcl-2 in Malignant Melanoma and Benign Melanocytic Nevi
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이성열/Lee SY
이종석/김현조/정 현/조현득/김의한/Lee JS/Kim HJ/Jung H/Cho HD/Kim EH
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Abstract
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Background: The bcl-2 protein, contrast to p53, has been shown to suppress the apoptosis, and overexpression of the bcl-2 protein has been reported in several malignant tumors. Although how the bcl-2 protein takes part in tumorigenesis has not been proved, the bcl-2 positive tumors appeared to have good prognosis in some malignant tumors. The expression pattern of the bcl-2 in melanocytic nevi and malignant melanoma have not been well known. The authors analyzed immunohistochemically expression of the bcl-2 protein to investigate the role of the bcl-2 protein in developing malignant melanoma.
Methods: 10 malignant melanoma and 10 benign melanocytic nevi were immunostained with anti-bcl-2 monoclonal antibody.
Results: In malignant melanoma, 1 case was 2+ positive, 9 cases were 3+ positive.
In benign melanocytic nevi, 2 cases were 2+ positive, 8 cases were 3+ positive.
Conclusion: Bcl-2 protein is expressed by benign melanocytic nevi and malignant melanoma. There is no difference bcl-2 protein expression in melanocytic nevi and maligant melanoma.
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KEYWORD
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